Peptide regulators of mitochondrial fusion and methods of use
AssigneesWashington University, Stanford University
InventorsDaria Mochly-Rosen, Gerald W. Dorn, II
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Abstract
Mitofusin modulatory peptides are described which may function as activators or inhibitors of mitochondrial fusion. The sequences and compositions comprising the sequences are useful for treating diseases or disorders associated with mitofusin 1 (Mfn1) and/or mitofusin 2 (Mfn2) and mitochondrial dysfunction. Methods of treatment, pharmaceutical formulations and methods of identifying compounds that mimic the activity of the peptides for use in screening assays are also described.
Claims12
A composition, comprising:
- a modulatory peptide having the an amino acid sequence selected from the sequences identified as SEQ ID NO:
- 14, SEQ ID NO:
- 48, and SEQ ID NO:
- 75;
- and a pharmaceutically acceptable carrier.
A modulatory peptide consisting of a sequence selected from the sequences identified as SEQ ID NO:
- 14, SEQ ID NO:
- 48, and SEQ ID NO:
- 75.
Dependencies are inferred from the claim text.