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AssigneeLoma Linda University
InventorsXiaolei Tang, David J. Baylink, K.-H. William Lau, Michael Walter
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Gene-modified, lymphoid-tissue-homing dendritic cells that comprise a 1-alpha-hydroxylase gene and a retinaldehyde dehydrogenase 2 gene, where the 1-alpha-hydroxylase gene is expressed to produce functional 1-alpha-hydroxylase enzyme and the retinaldehyde dehydrogenase 2 gene is expressed to produce functional retinaldehyde dehydrogenase 2 gene enzyme. A method for treating one or more than one inflammation-related condition or disease, the method comprising administering gene-modified, lymphoid-tissue-homing dendritic cells that comprise a 1-alpha-hydroxylase gene and a retinaldehyde dehydrogenase 2 gene, where the 1-alpha-hydroxylase gene is expressed to produce functional 1-alpha-hydroxylase enzyme and the retinaldehyde dehydrogenase 2 gene is expressed to produce functional retinaldehyde dehydrogenase 2 gene enzyme.
A method of treating a patient having an inflammatory bowel disease, the method comprising administering to the patient a gene-modified dendritic cell, the gene-modified dendritic cell comprising a cytochrome p450 family 27 subfamily B polypeptide 1 (CYP27B1) gene encoding 1-alpha-hydroxylase and an aldehyde dehydrogenase 1 family member A2 (ALDH1a2) gene encoding retinaldehyde dehydrogenase 2 (RALDH2), wherein the gene-modified dendritic cell is engineered to constitutively overexpress both the 1-alpha-hydroxylase and the RALDH2.
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