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US 10,577,427 B2Granted
Integral membrane protein display on poxvirus extracellular enveloped virions
AssigneeVaccinex, Inc.
InventorsErnest S. Smith, Mark Paris, Maria G. M. Scrivens, Renee A. Kirk, Angelica A. Cornelison
Life of this patent
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Abstract
This disclosure provides compositions and methods for expressing and displaying isolated integral membrane proteins (IMPs) or fragments thereof in a native conformation for use in the screening, selecting, and identifying of antibodies or antibody-like molecules that bind to a target IMP of interest.
Claims12
An IMP-EEV fusion protein, which comprises
- (a) an integral membrane protein (IMP) or fragment thereof, which comprises at least one extra-membrane region, at least one transmembrane domain, and at least one intra-membrane region;
- and
- (b) a vaccinia virus extracellular enveloped virion (EEV) protein or functional fragment thereof.
Dependencies are inferred from the claim text.