Fenofibric acid salt with berberine or its analogues, crystalline forms, methods of preparation, and applications thereof

A fenofibric acid salt with berberine or its analogues comprising neutralized fenofibric acid as an anion and berberine or berberine analog as a cation, wherein the salt has a molar ratio of the neutralized fenofibric acid and berberine or berberine analog of from about 0.9:1 to about 1:0.9;

• wherein the salt is a crystalline solid of at least about 90% crystalline material;
• wherein the berberine or berberine analog has one or more of the following structures;
• wherein R11 and R12 are independently H, CH3, or together a —CH2— or substituted —CH2— group;
• and R13 and R14 are independently H, CH3, or together a —CH2— or substituted —CH2— group;
• wherein R20 and R21 are independently H, CH3, or together a —CH2— or substituted —CH2— group;
• and R22 and R23 are independently H, CH3, or together a —CH2— or substituted —CH2— group;
• and
• wherein R24 and R25 are independently H, CH3, or together a —CH2— or substituted —CH2— group;
• and R26 and R27 are independently H, CH3, or together a —CH2— or substituted —CH2— group;
• R28 is H, CH3, OH, —OCH3, or —OCH2CH3.