Compositions and methods for treatment of prostate carcinoma
AssigneePellficure Pharmaceuticals, Inc.
InventorsPer Borgström, Adrian Chrastina, Veronique Therese Baron, Parisa Abedinpour
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Abstract
Disclosed herein are 1,4-naphthoquinone analogs, pharmaceutical compositions that include one or more of such 1,4-naphthoquinone analogs, and methods of treating and/or ameliorating diseases and/or conditions associated with a cancer, such as prostate cancer with such 1,4-naphthoquinone analogs. Also included are combination therapies wherein a 1,4-naphthoquinone analog disclosed herein, and a hormone therapy agent are provided to a subject suffering from a condition such as cancer.
Claims13
A method of inhibiting the growth of prostate cancer, comprising administering to a subject having prostate cancer a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof:
- wherein:
- R1 is 4-hydroxyphenoxy;
- R2 is hydrogen;
- wherein the growth of prostate cancer is inhibited;
- and, optionally,
- wherein the composition comprising a compound of Formula (I) is administered to the subject in combination with, subsequent to, or concomitantly with, an androgen deprivation therapy.
A product combination that inhibits prostate cancer in a subject, wherein the product combination comprises a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and a hormone therapy agent;
- and
- wherein the compound of Formula (I) has the following structure:
- wherein:
- R1 is 4-hydroxyphenoxy;
- and
- R2 is hydrogen.
Dependencies are inferred from the claim text.