Cholera toxin chimera and its use as a staph vaccine
AssigneeBoise State University
InventorJuliette Tinker
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Abstract
The present invention relates to chimeric protein vaccines and methods of use thereof in the treatment of Staphylococcus aureus. One embodiment of the present invention provides a method of generating an immune response in a mammal, that includes administering to the mammal, a composition having a chimeric protein having at least one of: a portion of a cholera toxin, a portion of a heat-labile toxin, and a portion of a shiga toxin; and an antigen having at least one of: an antigenic material from S. aureus and an antigenic material from a S. aureus-specific polypeptide.
Claims20
A chimeric protein capable of generating an immune response in a mammal comprising a truncated iron-regulated surface determinant B (IsdB) protein of Staphylococcus aureus consisting of amino acids 42-338 of SEQ ID NO:
- 23 and an adjuvant protein, wherein said adjuvant protein is cholera toxin subunit A2 (CTA2), cholera toxin subunit B (CTB), heat labile toxin subunit A2, heat labile toxin subunit B, Shiga toxin subunit A2, Shiga toxin subunit B, or any combination thereof.
A method of generating an immune response to Staphylococcus aureus in a mammal comprising administering to the mammal a composition comprising a chimeric protein, wherein the chimeric protein comprises a truncated iron-regulated surface determinant B (IsdB) protein of Staphylococcus aureus consisting of amino acids 42-338 of SEQ ID NO:
- 23 and an adjuvant protein, wherein said adjuvant protein is cholera toxin subunit A2 (CTA2), cholera toxin subunit B (CTB), heat labile toxin subunit A2, heat labile toxin subunit B, Shiga toxin subunit A2, Shiga toxin subunit B, or any combination thereof.
Dependencies are inferred from the claim text.