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US 10,571,468 B2Granted
Modified Fc gamma receptor type III (FCγIII, HNA-1) polypeptides and the uses thereof
AssigneeOne Lambda
InventorsJar-How Lee, Neng Jen Remi Shih, Julie Nguyen, Rui Pei
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Abstract
The invention is directed to engineered Fc gamma receptor type III (Fcγ111, HNA-1) polypeptides and use of these polypeptides to detect antibodies specific for human neutrophil antigens (HNA). The invention is also directed to methods for the diagnosing and determining susceptibility for developing Transfusion Reaction Acute Lung (TRALI).
Claims6
A purified Fc gamma receptor type IIIb polypeptide comprising the amino acid sequence of SEQ ID NO:
- 1, wherein the amino acid sequence of SEQ ID NO:
- 1 comprises a substitution wherein leucine at residue 136 of SEQ ID NO:
- 1 is substituted with alanine (L136A).
An antigenic peptide comprising the amino acid sequence of SEQ ID NO:
- 16.
Dependencies are inferred from the claim text.