Binding moieties for biofilm remediation
AssigneeTrellis Bioscience, LLC
InventorsLawrence M. Kauvar, Stefan Ryser, Angeles Estelles, Reyna J. Simon, Lauren Opremcak Bakaletz, Steven David Goodman
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Abstract
Binding agents able to disrupt bacterial biofilms of diverse origin are described, including monoclonal antibodies suitable for administration to a selected species, and antibody mimics including aptamer nucleic acids. Methods to prevent formation of or to dissolve biofilms with these binding agents are also described. Immunogens for eliciting antibodies to disrupt biofilms are also described.
Claims6
Recombinant host cells that have been modified to contain a recombinant expression system for producing an mAb or antigen binding fragment thereof wherein said expression system comprises one or more nucleotide sequences encoding at least the variable regions of said mAb operably linked to one or more heterologous control sequences for expression wherein
- the variable region of said mAb comprises the heavy and light chain variable regions of i) TRL1068 (SEQ ID NO:1 and SEQ ID NO:
- 2) or ii) of TRL1330 (SEQ ID NO:21 and SEQ ID NO:
- 22) or iii) of TRL1337 (SEQ ID NO:25 and SEQ ID NO:
- 26).
A recombinant expression system for producing an mAb or antigen-binding fragment thereof wherein said expression system comprises one or more nucleotide sequences encoding said at least the variable regions of said mAb operably linked to one or more heterologous control sequences for expression wherein
- the variable region of said mAb comprises the heavy and light chain variable regions of i) TRL1068 (SEQ ID NO:1 and SEQ ID NO:
- 2) or ii) of TRL1330 (SEQ ID NO:21 and SEQ ID NO:
- 22) or iii) of TRL1337 (SEQ ID NO:25 and SEQ ID NO:
- 26).
Dependencies are inferred from the claim text.