Medicant eluting adjuncts and methods of using medicant eluting adjuncts

A surgical method, comprising:

• positioning an end effector of a surgical stapler adjacent an organ of a patient, the end effector having disposed therein a cartridge body including a plurality of staples, and the end effector having a biocompatible adjunct material releasably disposed on a first external surface thereof, the adjunct material having a plurality of distinct regions each having an effective amount of at least one medicant disposed within and releasable therefrom;
• actuating the stapler to deploy the staples from the cartridge body, thereby stapling the adjunct material to the organ and releasing the adjunct material from the end effector, the plurality of distinct regions releasing the medicant in a predetermined spatial pattern, the adjunct material having a predetermined spatial structure, and the spatial pattern of the plurality of distinct regions and the spatial structure of the adjunct material encouraging regrowth of tissue of the organ in at least a first location on the organ and discourage regrowth of tissue in at least a second location of the organ, the plurality of distinct regions including a first fiber lattice section having a first plurality of fibers configured to encourage the regrowth and a second fiber lattice section having a second plurality of fibers being less tightly spaced relative to the fibers of the first plurality of fibers and configured to discourage the regrowth, the first and second fiber lattice sections being disposed together along a second external surface of the adjunct material, each fiber of the first plurality of fibers extending substantially parallel to each other fiber of the first plurality of fibers along the second external surface, and each fiber of the second plurality of fibers extending substantially parallel to each other fiber of the second plurality of fibers along the second external surface;
• and
• after the actuation, removing the end effector with the cartridge body disposed therein from the patient;
• wherein the first fiber lattice section has thin fibers configured to encourage regrowth, and the second fiber lattice section has thicker fibers relative to the thin fibers of the first fiber lattice section configured to discourage regrowth.

A surgical method, comprising:

• positioning an end effector of a surgical stapler adjacent an organ of a patient, the end effector having disposed therein a cartridge body including a plurality of staples, and the end effector having a biocompatible adjunct material releasably disposed on a first external surface thereof, the adjunct material having a plurality of distinct regions each having an effective amount of at least one medicant disposed within and releasable therefrom;
• actuating the stapler to deploy the staples from the cartridge body, thereby stapling the adjunct material to the organ and releasing the adjunct material from the end effector, the plurality of distinct regions releasing the medicant in a predetermined spatial pattern, the adjunct material having a predetermined spatial structure, and the spatial pattern of the plurality of distinct regions and the spatial structure of the adjunct material encouraging regrowth of tissue of the organ in at least a first location on the organ and discourage regrowth of tissue in at least a second location of the organ, the plurality of distinct regions including a first fiber lattice section having a first plurality of fibers configured to encourage the regrowth and a second fiber lattice section having a second plurality of fibers being less tightly spaced relative to the fibers of the first plurality of fibers and configured to discourage the regrowth, the first and second fiber lattice sections being disposed together along a second external surface of the adjunct material, each fiber of the first plurality of fibers extending substantially parallel to each other fiber of the first plurality of fibers along the second external surface, and each fiber of the second plurality of fibers extending substantially parallel to each other fiber of the second plurality of fibers along the second external surface;
• and
• after the actuation, removing the end effector with the cartridge body disposed therein from the patient;
• wherein the first fiber lattice section has positively charged fibers configured to encourage regrowth, and the second fiber lattice section has negatively charged fibers configured to discourage regrowth.