Compositions and methods for treating kabuki syndrome and related disorders
AssigneeThe Johns Hopkins University
InventorsHans Tomas Bjornsson, Harry Dietz, Joel Benjamin
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Abstract
A method is provided for treating a Mendelian disorder of the epigenetic machinery (e.g., Kabuki syndrome) in a subject in need thereof. In particular, the method comprises administering to the subject a ketogenic composition in an amount sufficient to produce a physiologically acceptable ketosis in the subject. A method for selecting a subject for treatment of a Mendelian disorder of the epigenetic machinery (e.g., Kabuki syndrome) is also provided. Ketogenic compositions and kits useful for practicing the methods are also provided.
Claims25
A method of treating Kabuki syndrome (KS) in a subject in need thereof, comprising administering to the subject a ketogenic composition in an amount sufficient to produce a physiologically acceptable ketosis in the subject and for a duration sufficient to treat KS in the subject.
A method of promoting a treatment for Kabuki syndrome (KS) in a subject in need thereof, wherein the treatment comprises administering a ketogenic composition in an amount sufficient to produce a physiologically acceptable ketosis in the subject and for a duration sufficient to promote treatment of KS in the subject.
Dependencies are inferred from the claim text.