Fluid handling cassette

A fluid handling and analysis system comprising:

• a main analysis and control instrument comprising a reusable optical sensor;
• and
• a disposable fluid handling module removably engageable with said main instrument;
• said main instrument further comprising a bodily fluid analyzer and at least one control element configured to mechanically interface with the disposable fluid handling module to control fluid flow through the disposable fluid handling module when the disposable fluid handling is removably engaged with the main instrument;
• said disposable fluid handling module further comprising a sample element and at least one fluid handling element, wherein said sample element is accessible via said fluid handling element and integrated therein to allow analysis of a fluid portion within a sample chamber of the sample element, said disposable fluid handling module further comprising a window positioned adjacent the reusable optical sensor and in an optical path for detection of fluid flow within the disposable fluid handling module, the optical path traversing the fluid at a position separate from the analysis portion within and proximate to an inlet of the disposable fluid handing module;
• and
• said at least one fluid handling element having a control interface configured to engage said at least one control element when said main instrument and said disposable fluid handling module are removably engaged.