Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of threonyl-tRNA synthetases
AssigneesaTyr Pharma, Inc., Pangu BioPharma Limited
InventorsLeslie Ann Greene, Kyle P. Chiang, Fei Hong, Alain P. Vasserot, Wing-Sze Lo, Jeffry D. Watkins, Cheryl L. Quinn, John D. Mendlein
Life of this patent
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Abstract
Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
Claims12
A therapeutic composition, comprising an isolated aminoacyl-tRNA synthetase (AARS) polypeptide that is at least 95%, 98%, or 100% identical to a sequence selected from:
- (a) SEQ ID NO:
- 14 or 26 or a fragment thereof which is 100 or more contiguous amino acids of SEQ ID NO:
- 14 or 26;
- (b) SEQ ID NO:
- 12 or 24 or a fragment thereof which is 300 or more contiguous amino acids of SEQ ID NO:
- 12 or 24;
- and
- (c) SEQ ID NO:
- 50 or 58 or a fragment thereof which is 400 or more contiguous amino acids of SEQ ID NO:
- 50 or 58,
- wherein the AARS polypeptide has an extracellular signaling activity and a solubility of at least about 5 mg/mL, and wherein the composition has a purity of at least about 95% on a protein basis and less than about 10 EU endotoxin/mg protein.
An isolated aminoacyl-tRNA synthetase (AARS) polypeptide that is at least 95%, 98%, or 100% identical to an amino acid sequence selected from:
- (a) SEQ ID NO:
- 14 or 26 or a fragment thereof which is 100 or more contiguous amino acids of SEQ ID NO:
- 14 or 26;
- (b) SEQ ID NO:
- 12 or 24 or a fragment thereof which is 300 or more contiguous amino acids of SEQ ID NO:
- 12 or 24;
- and
- (c) SEQ ID NO:
- 50 or 58 or a fragment thereof which is 400 or more contiguous amino acids of SEQ ID NO:
- 50 or 58,
- wherein the AARS polypeptide has an extracellular signaling activity.
Dependencies are inferred from the claim text.