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US 10,563,179 B2Granted
Compositions and methods for antigen targeting to CD180
AssigneeUniversity of Washington through its Center for Commercialization
InventorsEdward Clark, Jay Wesley Chaplin
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Abstract
The present invention provides compositions of CD180 targeting molecules coupled to heterologous antigens, and their use in treating and/or limiting disease.
Claims19
A composition, comprising:
- (a) an antibody that selectively binds CD180 or an antigen binding fragment thereof;
- and
- (b) a heterologous polypeptide antigen covalently attached to the antibody that selectively binds CD180 or the antigen binding fragment thereof, wherein the heterologous polypeptide antigen is selected from the group consisting of a pathogen-specific polypeptide antigen and a disease-related polypeptide antigen.
Dependencies are inferred from the claim text.