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US 10,563,178 B2Granted
PIV5-based amplifying virus-like particles
AssigneeUniversity of Georgia Research Foundation, Inc.
InventorBiao He
Life of this patent
Estimating the term…
Abstract
Compositions, methods of use and methods of manufacture are provided for PIV5-based amplifying VLP (AVLP) that can deliver an expressible heterologous nucleotide sequence in target cells without producing progeny, and which demonstrate useful safety and therapeutic efficacy in multiple animal and human health applications, such as vaccination, gene therapy and cancer therapy.
Claims15
An amplifying virus-like particle consisting of:
- (i) an isolated polynucleotide sequence consisting of genes encoding a PIV5 nucleocapsid protein (NP), a PIV5 phosphoprotein (V/P) and a PIV5 large RNA polymerase (L), and
- (ii) an expressible heterologous non-PIV5 nucleotide sequence between the V/P and L genes.
Dependencies are inferred from the claim text.