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US 10,562,835 B1Granted
Method for producing thorium-226
AssigneeTriad National Security, LLC
InventorsMichael E. Fassbender, Tara E. Mastren
Life of this patent
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Abstract
Disclosed herein are embodiments of a method for producing thorium-226. The method comprises separating thorium-226 from uranium-230 to produce a solution of thorium-226 in a solvent, such as a chelating buffer, suitable for direct labeling by a chelate. The thorium-226 may be separated from the uranium-230 using extraction chromatography. The extraction may be repeated multiple times as additional thorium-226 is produced by uranium-230 decay.
Claims19
A method, comprising:
- forming a first solution comprising uranium-230 and thorium-226;
- contacting a first resin with the first solution such that the uranium-230 and the thorium-226 bind to the first resin, wherein the first resin is a diglycolamide resin, a monoamide resin, a malonamide resin, or a multi-podant DGA ligand,
- eluting the thorium-226 from the first resin with a carboxylic acid-based chelating buffer to form a second solution comprising the thorium-226 and the carboxylic acid-based chelating buffer.
A method, comprising:
- forming a first solution comprising uranium-230 and thorium-226;
- contacting a first resin selected from a phosphonic acid resin, a phosphine oxide resin, or a phosphine sulfide resin with the first solution such that the uranium-230 and the thorium-226 bind to the first resin;
- eluting the thorium-226 from the first resin with a mineral acid to form a second solution, the mineral acid having an acid concentration of from 0.5 M to 4 M;
- contacting a cation exchange resin with the second solution;
- and
- eluting the thorium-226 from the cation exchange resin with the chelating buffer to form a third solution.
3 more elements
A method, comprising:
- forming a first solution comprising uranium-230 and thorium-226 in 6M hydrochloric acid;
- contacting a diglycolamide resin with the first solution to bind the uranium-230 and thorium-226 to the resin;
- eluting the uranium-230 from the resin with nitric acid having a nitric acid concentration of from 0.01 M to 0.25 M, to form a second solution comprising uranium-230;
- eluting the thorium-226 from the resin with a chelating buffer to form a third solution comprising thorium-226, the chelating buffer comprising a carboxylic acid and having a pH of from 2 to 6.
1 more element
Dependencies are inferred from the claim text.