Rapid action insulin formulations and pharmaceutical delivery systems

An infusion set comprising a first body, an adhesive surface, a subcutaneous infusion catheter, a pharmaceutical composition reservoir comprising an insulin formulation, a supply tube operably connected to the reservoir, and a pump and controller operably connected to the reservoir delivering the insulin formulation through the supply tube to the catheter:

• the infusion set further comprising one or more of an ultrasound transducer, a tactor, and an electrophoresis electrode that increases the rate at which the insulin formulation is absorbed into the circulation of a subject from a subcutaneous depot as compared to absorption from the subcutaneous depot without the transducer, tactor, and/or electrophoresis electrode;
• and
• wherein the insulin formulation comprises a stable monomeric insulin analogue or dimeric insulin analogue formulated at about U100 or greater and a pharmaceutically acceptable excipient or carrier.