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US 10,556,875 B2Granted
Bis-diazeniumdiolate compounds as anti-cancer agents
AssigneeArizona Board of Regents on behalf of Arizona State University
InventorShengxi Chen
Life of this patent
Estimating the term…
Abstract
A series of double-component, bis O2-aryl diazeniumdiolate derivatives are provided, of which each molecule can release up to four nitric oxide molecules. These compounds show cytotoxic activities to cancer cells, such as human leukemia, breast cancer and lung cancer. Among them, the compound 3 showed the highest specific activity against human leukemia cells.
Claims14
A compound selected from formula I:
- wherein:
- X is CH or N;
- and
- L is selected from C1-C10 alkyldiyl, C1-C10 alkyldiyl-(C3-C6 cycloalkyldiyl), and C1-C10 alkyldiyl-(C3-C6 cycloalkyldiyl)-C1-C10 alkyldiyl, where alkyldiyl and cycloalkyldiyl are independently and optionally substituted with one or more groups selected from halo, hydroxy, nitro, cyano, (C1-C6) alkoxy, and oxo (═O);
- or a pharmaceutically-acceptable salt thereof.
2 more elements
A compound selected from compounds 1-4:
Dependencies are inferred from the claim text.