Bimodal ligands with macrocyclic and acyclic binding moieties, complexes and compositions thereof, and methods of using

A compound of formula (II):

• wherein:
• R′ independently is OH, NH2, or OR″, wherein R″ independently is alkyl, tert-butyl, or benzyl;
• m is 0 or 1;
• and Y is a structure of formula (a-1) or (a-2):
• where:
• p is 0 or 1;
• Z is hydrogen, one of a group of formula (a-5), (a-6), or (a-7), or
• W is NH2;
• and each of R1-18 independently is or includes hydrogen, carboxyalkyl, alkylamido, alkyl, allyl, benzyl, benzyloxyalkyl, cycloalkyl, alkoxy, hydroxyalkyl, aryl, aryloxy, hydroxyaryl, heteroaryl, phenyl, vinyl, alkynyl, alkenyl, furannylalkyl, alkylthioalkyl, arylhydroxyalkyl, indanyl, inolylalkyl, naphthylalkyl, imidazolylalkyl, pyridiylalkyl, benzothiophenylalkyl, thiophenylalkyl, thioalkyl, thioaryl, thiobenzyl, hydroxy, carboxyl, carboxyalkyloxy, amino, carboxylic acid, haloalkylamido, aldehyde, ester, amido, tosyl, phthalimidyl, trityl, tert-butyloxycarbonyl, carbobenzyloxy, o-nosyl, acetyl, fluoroacetyl, dimethoxybenzyl, p-methoxybenzyl, an amide containing group, a thioamide containing group, an amino acid-containing group, an ester containing group, a protecting group, or one of the group of formula (a-5), (a-6), or (a-7):
• where n is 1 to 10, and each of X1-5 is or includes hydrogen, halo, cyano, alkyl, hydroxy, nitro, amino, alkylamino, thiocyano, isothiocyano, alkoxy, aryloxy, carboxyl, carboxyalkyl, carboxyalkyloxy, ester, amido, aldehydo, alkylamido, haloalkylamido, an ester containing group, an carbonyl containing group, an amide containing group, a thioamide containing group, or an amino acid-containing group, wherein when Y is the structure of formula (a-1) at least one R′ of formula (a-1) is NH2.