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AssigneeSENTINEXT THERAPEUTICS Sdn Bhd
InventorsMary Jane Cardosa, Mohamad Fakruddin Jamiluddin, Sharifah Binti Hamid
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The instant invention provides materials and methods for producing immunologically active antigens derived from members of the Picornaviridae virus family. The picornavirus antigens of the invention may be in a form for use as a vaccine administered to a subject in a therapeutic treatment or for the prevention of a picornavirus infection. The picornavirus antigens of the invention may be in the form of an immunogenic composition for use in vaccines which are administered for the prevention of an Enterovirus infection. The instant invention further encompasses immunogenic compositions comprising Human enterovirus A, Human enterovirus B, Human enterovirus C, Human enterovirus D antigens and their use in vaccines for the prevention of an Enterovirus infection.
An expression cassette comprising a promoter operably linked to a nucleic acid sequence encoding a human enterovirus C P1 polypeptide, wherein the nucleic acid sequence encoding the human enterovirus C P1 polypeptide is operably linked to a nucleic acid sequence encoding a human enterovirus C Internal Ribosome Entry Site (IRES), wherein the nucleic acid sequence encoding the IRES is operably linked to a nucleic acid sequence encoding a human enterovirus C 3CD protease, wherein the human enterovirus C 3CD protease is under the translational control of the IRES.
Dependencies are inferred from the claim text.