Therapeutic effects of NURR1 and FOXA2 in inflammatory neurologic disorders by M1-to-M2 polarization of glial cells
AssigneeInnopeutics Corporation
InventorsSang-Hun Lee, Sang-Min Oh
Life of this patent
Estimating the term…
Abstract
A therapeutic effect of Nurr1 and Foxa2 in inflammatory neurologic disorders by M1-to-M2 polarization of glial cells is provided. Specifically, a method of converting glial cells from an M1 phenotype to an M2 phenotype, wherein Nurr1 and Foxa2 are introduced into the glial cells to be overexpressed in the glial cells and a method of preventing or treating an inflammatory neurologic disorder, which includes glial cells into which Nurr1 and Foxa2 are introduced, or a viral vector loaded with Nurr1 and Foxa2, are provided.
Claims13
A method of protecting brain neurons from cell damage comprising:
- administering to a mammal a recombinant viral vector comprising a nucleic acid expressing Nuclear receptor-related factor 1 (Nurr1) and forkhead box protein A2 (Foxa2) to transduce glial cells that are adjacent to neurons to form transduced glial cells;
- and
- expressing Nurr1 and Foxa2 proteins from the recombinant viral vector, wherein expression of both Nurr1 and Foxa2 proteins in the transduced glial cells reduces secretion of one or more inflammatory factors and increases secretion of one or more neurotrophic factors that protect the neurons from cell damage relative to transduced glial cells expressing Nurr1 or Foxa2 alone.
A method of protecting brain neurons from cell damage in a mammalian subject in need thereof, comprising:
- injecting into the subject a recombinant viral vector comprising a nucleic acid expressing Nuclear receptor-related factor 1 (Nurr1) and forkhead box protein A2 (Foxa2) to target and transduce brain glial cells;
- and
- expressing Nurr1 and Foxa2 proteins from the recombinant viral vector, wherein expression of both Nurr1 and Foxa2 proteins in the transduced brain glial cells reduces secretion of one or more inflammatory factors and increases secretion of one or more neurotrophic factors that protect neurons from cell damage relative to transduced brain glial cells expressing Nurr1 or Foxa2 alone.
Dependencies are inferred from the claim text.