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US 10,555,677 B2Granted
Method and device for improving prediction and detection of change in a physiological condition
AssigneeMedicus Engineering Aps
InventorsJesper Fleischer, Simon Lebech Cichosz
Life of this patent
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Abstract
Devices, methods and systems for predicting and detecting a change in a physiological condition of a subject are disclosed. A device for detecting and predicting a change in physiological condition of a subject may include one or more processors configured to: (i) analyze changes in a heart rhythm of a subject; (ii) analyze a signal from one or more biomarkers that are associated with a physiological condition of the subject; and (iii) determine, based on the changes in the heart rhythm and the signal from the one or more biomarkers, whether there is a change in the physiological condition of the subject during a time period.
Claims28
A device comprising one or more processors configured to:
- obtain continuously over time, via one or more sensors, both a heart rhythm signal related to a heart rhythm of a subject and an interstitial fluid glucose level signal related to a glucose level of an interstitial fluid of the subject;
- analyze continuously over time changes in a pattern of a heart rate variability of the subject based on the heart rhythm signal;
- analyze continuously over time changes in the glucose level of the interstitial fluid based on the interstitial fluid glucose level signal;
- extract features from the pattern of the heart rate variability and the glucose level of the interstitial fluid;
- reduce the features extracted based on a ranking algorithm to eliminate certain features that do not signify a physiological event;
- combine the pattern of the heart rate variability and the interstitial fluid glucose level signal;
- and
- predict, for a physiological condition during a future time period of the subject for which the glucose level of the interstitial fluid is surrogate measurement, whether there would be a change in the physiological condition of the subject during the future time period, a prediction being based on the correlated changes in the pattern of the heart rate variability and the changes in the glucose level of the interstitial fluid, wherein a continuous glucose monitor is a surrogate measure for blood glucose measurement.
5 more elements
A method comprising:
- obtaining continuously over time, via one or more sensors, both a heart rhythm signal related to a heart rhythm of a subject and an interstitial fluid glucose level signal related to a glucose level of an interstitial fluid of the subject;
- analyzing continuously over time, via one or more processors, changes in a dynamic pattern of a heart rate variability of the subject based on the heart rhythm signal;
- analyzing continuously over time, via one or more processors, changes in the glucose level of the interstitial fluid based on the interstitial fluid glucose level signal;
- extracting features from the dynamic pattern of the heart rate variability and the glucose level of the interstitial fluid;
- combining the dynamic pattern of the heart rate variability and the interstitial fluid glucose level signal;
- extracting features based on a ranking algorithm to eliminate a lag-time between a continuous glucose monitor measurement and an actual blood glucose level;
- and
- predicting, via the one or more processors, for a physiological condition during a future time period of the subject for which the glucose level of the interstitial fluid is a surrogate measurement, whether there would be a change in the physiological condition of the subject during the future time period, a prediction being based on the correlated changes in the complex dynamic/pattern of heart rate variability and the changes in the glucose level of the interstitial fluid, wherein a continuous glucose monitor is a surrogate measure for blood glucose measurement.
5 more elements
A system comprising:
- one or more sensors configured to obtain continuously over time a heart rhythm signal related to a heart rhythm of a subject and to obtain continuously over time an interstitial fluid glucose level signal related to a glucose level of an interstitial fluid of the subject;
- a device comprising one or more processors configured to:
- obtain continuously over time, via the one or more sensors, a pattern of a heart rhythm signal and the interstitial fluid glucose level signal;
- analyze continuously over time changes in a pattern of a heart rate variability of the subject based on the heart rhythm signal;
- analyze continuously over time changes in the glucose level of the interstitial fluid based on the interstitial fluid glucose level signal;
- combine the pattern of the heart rate variability and the interstitial fluid glucose level signal;
- and
- predict, for a physiological condition during a future time period of the subject for which the glucose level of the interstitial fluid is a surrogate measurement, weather there would be a change in the physiological condition of the subject during the future time period, a prediction being based on the correlated changes in the pattern of the heart rate variability and the changes in the glucose level of the interstitial fluid,
- wherein a continuous glucose monitor is a surrogate measure for blood glucose measurement.
6 more elements
Dependencies are inferred from the claim text.