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US 10,550,188 B2Granted
Nucleic acid-polypeptide compositions and uses thereof
AssigneeAvidity Biosciences, Inc.
InventorsAndrew John Geall, Venkata Ramana Doppalapudi, David Sai-Ho Chu, Michael Caramian Cochran, Rachel Elizabeth Johns, Palani Balu, Rob Burke, Beatrice Diana Darimont
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Abstract
Disclosed herein are compositions and pharmaceutical formulations that comprise a binding moiety conjugated to a polynucleic acid molecule and a polymer. Also described herein include methods for treating a cancer which utilize a composition or a pharmaceutical formulation comprising a binding moiety conjugated to a polynucleic acid molecule and a polymer.
Claims13
A composition comprising:
- an anti-transferrin receptor antibody or its binding fragments thereof;
- a double-stranded siRNA molecule consisting of a passenger strand and a guide strand;
- and
- a polymer conjugated to the 3′ terminus of the passenger strand;
- wherein said double-stranded siRNA molecule is conjugated to a cysteine of said antibody by a linker;
- wherein said double-stranded siRNA molecule comprises at least one 2′ modified nucleotide, at least one modified internucleotide linkage, or at least one inverted abasic moiety;
- and
- wherein the linker is conjugated to the 5′ terminus of the passenger strand of said double stranded siRNA molecule.
5 more elements
Dependencies are inferred from the claim text.