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US 10,550,145 B2Granted
Single-stranded DNA nanostructures
AssigneePresident and Fellows of Harvard College
InventorsDongran Han, Cameron Myhrvold, Peng Yin
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Abstract
The present disclosure relates to nanostructures assembled from nucleic acid consisting of a single strand of DNA rationally-designed to self-assemble into a hairpin loop, helical domains, and locking domains.
Claims15
A nanostructure formed from a single strand of DNA, wherein the nanostructure comprises:
- a first layer containing helical domains and locking domains, wherein at least two helical domains of the first layer are separated from each other by a locking domain;
- a second layer comprising helical domains and locking domains, wherein at least two helical domains of the second layer are separated from each other by a locking domain;
- and
- loop domains that connect one helical domain to another helical domain and are located along the periphery of the nanostructure,
- wherein a locking domain of the first layer is hybridized to a locking domain of the second layer.
2 more elements
Dependencies are inferred from the claim text.