Amino acid derivatives and absorbable polymers therefrom
AssigneeBezwada Biomedical, LLC
InventorRao S Bezwada
Life of this patent
Estimating the term…
Abstract
The present invention relates to the discovery of new class of hydrolysable amino acid derivatives and absorbable polyester amides, polyamides, polyepoxides, polyureas and polyurethanes prepared therefrom. The resultant absorbable polymers are useful for drug delivery, tissue engineering, tissue adhesives, adhesion prevention, bone wax formulations, medical device coatings, stents, stent coatings, highly porous foams, reticulated foams, wound care, cardiovascular applications, orthopedic devices, surface modifying agents and other implantable medical devices. In addition, these absorbable polymers should have a controlled degradation profile.
Claims17
An absorbable compound of formula E:
- wherein:
- each X is independently selected from:
- —OCH2C(O)—;
- —OCH(CH3)C(O)—;
- —OCH2CH2OCH2C(O)—;
- —OCH2CH2CH2CH2CH2C(O)—;
- —O(CH2)yC(O)—;
- and,
- —O(CH2CH2O)mCH2C(O)—;
- each Y is independently selected from:
- —C(O)CH2O—;
- —C(O)CH(CH3)O—;
- —C(O)CH2OCH2CH2O—;
- —C(O)CH2CH2CH2CH2CH2O—;
- —C(O)(CH2)yO—;
- and,
- —C(O)(CH2CH2O)mCH2O—;
- m is integer between 2-24 inclusive;
- p is 1;
- y is one of the numbers 2, 3, 4, and 6-24;
- wherein the H2N—R—C(O)O and OC(O)—R—NH2 moieties of Formula E (O being from an X or Y group) are an amino acid selected from:
- alanine, asparagine, aspartic acid, gamma amino butyric acid, glycine, glutamic acid, valine, lysine, isoleucine, leucine, and ornithine;
- and,
- R′ is selected from alkyl, aryl and arylalkyl, wherein the alkyl moiety, when present, comprises a primary chain of 2-24 carbon atoms;
- optionally, in R′, one or more CH2 groups in the primary chain are replaced with 0 or S;
- and,
- optionally, in R′, the primary chain or aryl is independently substituted with lower alkyl group(s).
Dependencies are inferred from the claim text.