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US 10,550,069 B2Granted
L-ornithine phenyl acetate and methods of making thereof
AssigneeOcera Therapeutics, Inc.
InventorsKeith E. Anderson, Jim Behling, Christine Henderson Dougan, Stephen William Watt, Peter Manini, Attilia Figini
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Abstract
Disclosed herein are forms of L-ornithine phenyl acetate and methods of making the same. A crystalline form may, in some embodiments, be Forms I, II, III and V, or mixtures thereof. The crystalline forms may be formulated for treating subjects with liver disorders, such as hepatic encephalopathy. Accordingly, some embodiments include formulations and methods of administering L-ornithine phenyl acetate.
Claims17
A process for making L-ornithine phenylacetate, comprising:
- forming a solution of L-ornithine;
- adding a pH modifier to the solution;
- adding phenylacetic acid to the solution;
- and
- isolating L-ornithine phenylacetate from the solution.
2 more elements
Dependencies are inferred from the claim text.