Methods for cancer treatment
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsRobert Lowsky, Edgar George Engleman, Samuel Strober
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Abstract
Residual, refractory or relapsed cancer is treated by immunostimulation in the presence of allogeneic immune effector cells, optimally in combination with radiation therapy. The methods of the disclosure induce a systemic allogeneic anti-tumor immune response that results in tumor regression in untreated sites of disease, i.e. non-injected, non-irradiated, etc.
Claims11
A method of treating a cancer in a subject, the method comprising intratumorally administering into a tumor in the subject that has undergone an allogenic hematopoietic stem cell transplantation an immunostimulant while concurrently providing local field irradiation of the tumor in the subject's body, wherein a combination of the immunostimulant and the local field irradiation induces allogeneic immune cells to generate an anti-tumor response to HLA alloantigens expressed by the tumor, causing a systemic allogeneic anti-tumor T-cell immune response that results in tumor regression in a second, untreated site of disease in the subject's body, and wherein the method is conducted without use of a chemotherapeutic agent.
Dependencies are inferred from the claim text.