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US 10,548,984 B2Granted
RVG Derived peptides
AssigneeUnited Arab Emirates University
InventorOmar M. Ali El-Agnaf
Life of this patent
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Abstract
The invention relates to short RVG derived peptides for use in delivering therapeutic agents across the blood brain barrier and to target cells, for example those cells in the central nervous system. The invention provides method and compositions to treat diseases, such as neurodegenerative diseases, with therapeutic agents associated with targeting peptides.
Claims17
A peptide consists of the structure:
- A1-B—C or C-B-A2, wherein B is optionally present or absent;
- and wherein
- A1 comprises the sequence CDIFTNSRGK (SEQ ID NO:2);
- A2 comprises the sequence kGrsntfidc (SEQ ID NO:3);
- B is a linker sequence;
- and
- C is a cell penetrating peptide (CPP) sequence, wherein the cell penetrating peptide sequence is a polymeric arginine residue sequence,
- wherein A1 and A2 consists of a length of less than 15 residues and
- wherein, if present, the linker sequence consists of a plurality of glycine or sarcosine residues.
6 more elements
Dependencies are inferred from the claim text.