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US 10,548,970 B2Granted
Human rotavirus G9P[6] strain and use as a vaccine
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsBaoming Jiang, Yuhuan Wang
Life of this patent
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Abstract
Attenuated G9P[6] rotavirus is disclosed herein. In some embodiments, pharmaceutical compositions are disclosed that include an attenuated G9P[6] rotavirus, or a component thereof. These compositions can be used to induce an immune response, such as a protective immune response, to a rotavirus. The compositions can be used as vaccines, such as for children (infants), for example in a prime boost strategy.
Claims23
An isolated attenuated rotavirus, comprising:
- a) a nucleic acid molecule encoding a polypeptide comprising an amino acid sequence at least 99.8% identical to the amino acid sequence set forth as SEQ ID NO:
- 1 (VP1);
- b) a nucleic acid molecule encoding a polypeptide comprising the amino acid sequence set forth as SEQ ID NO:
- 2 (VP2);
- c) a nucleic acid molecule encoding a polypeptide comprising an amino acid sequence at least 99.6% identical to the amino acid sequence set forth as SEQ ID NO:
- 3 (VP3);
- d) a nucleic acid molecule encoding a polypeptide comprising an amino acid sequence at least 99.1% identical to the amino acid sequence set forth as SEQ ID NO:
- 4 (VP4);
- e) a nucleic acid molecule encoding a polypeptide comprising the amino acid sequence set forth as SEQ ID NO:
- 5 (VP6);
- f) a nucleic acid molecule encoding a polypeptide comprising an amino acid sequence at least 98.9% identical to the amino acid sequence set forth as SEQ ID NO:
- 6 (VP7);
- h) a nucleic acid molecule encoding a polypeptide comprising an amino acid sequence at least 98.9% identical to the amino acid sequence set forth as SEQ ID NO:
- 7 (NSP1);
- i) a nucleic acid molecule encoding a polypeptide comprising the amino acid sequence set forth as SEQ ID NO:
- 8 (NSP2);
- j) a nucleic acid molecule encoding a polypeptide comprising an amino acid sequence at least 98.8% identical to the amino acid sequence set forth as SEQ ID NO:
- 9 (NSP3);
- k) a nucleic acid molecule encoding a polypeptide comprising the amino acid sequence set forth as SEQ ID NO:
- 10 (NSP4);
- and
- l) a nucleic acid molecule encoding a polypeptide comprising an amino acid sequence at least 99.6% identical to the amino acid sequence set forth as SEQ ID NO:
- 11 (NSP5),
- wherein the rotavirus is a G9P[6] rotavirus.
21 more elements
Dependencies are inferred from the claim text.