Topical compositions comprising OB-fold variants
AssigneeAffilogic
InventorOlivier Kitten
Life of this patent
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Abstract
The invention relates to a topical composition containing a variant of an OB-fold protein, and also to the process for preparing the same.
Claims10
A method for administering a variant of a wild-type OB-fold protein, the method comprising topically applying a dermatological composition comprising said variant on skin of a patient, wherein said variant passes through the skin of the patient, and wherein said variant has between 5 and 20 mutated residues in the interface of binding of said wild-type OB-fold protein to its natural ligand, wherein said wild-type OB-fold protein is selected from the group consisting of Sac7d or Sac7e derived from Sulfolobus acidocaldarius, Sso7d derived from Sulfolobus solfataricus, DBP 7 derived from Sulfolobus tokodaii, Ssh7b derived from Sulfolobus shibatae, Ssh7a derived from Sulfolobus shibatae, and p7ss derived from Sulfolobus solfataricus, and wherein said mutated residues are selected from the group consisting of V2, K3, K5, K7, Y8, K9, G10, E14, T17, K21, K22, W24, V26, G27, K28, M29, S31, T33, D36, N37, G38, K39, T40, R42, A44, S46, E47, K48, D49, A50 and P51 of Sac7d.
A method for having a protein penetrate through the skin of a patient, the method comprising topically applying a dermatological composition comprising said variant on skin of the patient, wherein said variant passes through the skin of the patient, and wherein said variant has between 5 and 20 mutated residues in the interface of binding of said wild-type OB-fold protein to its natural ligand, wherein said wild-type OB-fold protein is selected from the group consisting of Sac7d or Sac7e derived from Sulfolobus acidocaldarius, Sso7d derived from Sulfolobus solfataricus, DBP 7 derived from Sulfolobus tokodaii, Ssh7b derived from Sulfolobus shibatae, Ssh7a derived from Sulfolobus shibatae, and p7ss derived from Sulfolobus solfataricus, and wherein said mutated residues are selected from the group consisting of V2, K3, K5, K7, Y8, K9, G10, E14, T17, K21, K22, W24, V26, G27, K28, M29, S31, T33, D36, N37, G38, K39, T40, R42, A44, S46, E47, K48, D49, A50 and P51 Sac7d.
Dependencies are inferred from the claim text.