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US 10,548,944 B1Granted
Antimicrobial peptides and methods of using the same
AssigneeRiptide Bioscience, Inc.
InventorsJesse Jaynes, L. Edward Clemens, Henry Willfred Lopez, George R. Martin, Kathryn Woodburn
Life of this patent
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Abstract
Aspects of the present invention relate to peptides having antimicrobial activity. In certain aspects, the invention relates to peptides having potent antimicrobial activity, broad-spectrum antimicrobial activity, and/or the ability to kill otherwise antibiotic-resistant microbes, or microbes protected by biofilms.
Claims23
An antimicrobial peptide, comprising:
- a) a peptide sequence selected from:
- FIOKFAKOFKOFIOKFAKFAFAF(RP551) (SEQ ID NO:
- 2);
- FAFAFKAFKKAFKOFOOAFOOAF(RP552) (SEQ ID NO:
- 3);
- FOIKARFOVRARLOLKI(RP553) (SEQ ID NO:
- 4);
- FRLKIKARLKVKIRFKL(RP554) (SEQ ID NO:
- 5);
- FOLOAOIOVOLOAOIOL(RP555) (SEQ ID NO:
- 6);
- FOLOAOIKVKLOAOIOL(RP556) (SEQ ID NO:
- 7);
- RFCWKVCYKGICFKKCK(RP557) (SEQ ID NO:
- 8);
- OWCFOVCYOGICYOOCO(RP559) (SEQ ID NO:
- 10);
- OFCWOVCYOGICFOOCO(RP561) (SEQ ID NO:
- 12);
- OCOOFCIGOYCVOWCFO(RP562) (SEQ ID NO:
- 13);
- FOIOAOLOGGCLGOFCGGOIOAOLOF(RP565) (SEQ ID NO:
- 16);
- FOIKAOLGGCLGKFCGGIKAOLKF(RP566) (SEQ ID NO:
- 17);
- and
- FOIKAOLKGGCLGKFCGGKIKAOLKF(RP567) (SEQ ID NO:
- 18).
25 more elements
An antimicrobial peptide comprising:
- a) a peptide sequence selected from SEQ ID NO:
- 2,4-8, 10, 12, 13 and 18;
- or
- b) a sequence having five or less amino acid substitutions relative to the sequence defined in a), wherein the five or less amino acid substitutions consist of substitution of a cationic amino acid of the sequence with an alternative cationic amino acid residue;
- or
- c) a peptide sequence having at least 90% sequence identity with a sequence selected from SEQ ID NO:
- 2, 4-8, 10, 12, 13 and 18.
4 more elements
An antimicrobial peptide, comprising the sequence RWCFKVCYKGICYKKCK (RP560) (SEQ ID NO:
- 11).
Dependencies are inferred from the claim text.