Compositions and methods for preventing and treating heterotopic ossification and pathologic calcification

A method for treating heterotopic ossification, vascular calcification, or other pathologic calcification in a patient, comprising:

• administering to said patient:
• a) a combination of a Hedgehog (Hh) pathway antagonist together with:
• i) vitamin D, cholecalciferol or a vitamin D analog;
• or
• ii) a statin;
• b) a combination of:
• i) vitamin D, cholecalciferol or a vitamin D analog;
• and
• ii) a statin;
• or
• c) a combination of:
• i) a Hh pathway antagonist;
• ii) vitamin D, cholecalciferol or a vitamin D analog;
• and
• iii) a statin;
• wherein the compounds of paragraphs a), b) and c), are administered to the patient in a co-timely manner and wherein the compounds are present in an amount sufficient to make the combination effective at treating said heterotopic ossification, vascular calcification, or other pathologic calcification.

A pharmaceutical composition in unit dosage form comprising:

• a) a combination of a Hedgehog (Hh) pathway antagonist together with:
• i) vitamin D, cholecalciferol or a vitamin D analog;
• or
• ii) a statin;
• or
• b) a combination of:
• i) an Hh pathway antagonist;
• ii) vitamin D, cholecalciferol or a vitamin D analog;
• and
• iii) a statin;
• wherein the pharmaceutical composition comprises the compounds of either paragraph a) or paragraph b) along with a pharmaceutically acceptable carrier.