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US 10,544,440 B2Granted
Multiple protease deficient filamentous fungal cells and methods of use thereof
AssigneeGlykos Finland Oy
InventorsChristopher Landowski, Anne Huuskonen, Ann Westerholm-Parvinen, Markku Saloheimo, Anne Kanerva, Jukka Hiltunen
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Abstract
The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
Claims15
A Myceliophthora thermophila filamentous fungal cell comprising at least one endogenous sep protease having no protease activity and a recombinant polynucleotide encoding a mammalian polypeptide, wherein a gene encoding an endogenous sep protease of SEQ ID NO:
- 792, 794 or a gene encoding sep protease having at least 99% identity to SEQ ID NO:
- 797 of the Myceliophthora thermophila filamentous fungal cell comprises a mutation that eliminates the activity of the endogenous sep protease.
Dependencies are inferred from the claim text.