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US 10,544,186 B2Granted
Process for the synthesis of amide bonds with the aid of novel catalysts
AssigneeMerck Patent GmbH
InventorsNikolai Mykola Ignatyev, Walter Frank, Peter Barthen, Myroslav Vysotsky
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Abstract
The invention relates to a process for the production of amide bonds, in particular peptide bonds, with the aid of novel amide linking reagents containing an anion of the formula (I), to the novel reagents, and to the preparation thereof.
Claims7
A process for production of an amide bond comprising:
- reacting an acid with a primary or secondary amine in the presence of a base with the aid of at least one amide linking reagent, wherein said at least one amide linking reagent contains an anion of formula (I),
- [P(CnF2n+1)yF6-y]− (I),
- where
- n stands on each occurrence, independently, for 1, 2, 3, 4, 5, 6, 7 or 8 and
- y stands for 1, 2, 3 or 4.
2 more elements
A compound selected from the following group of compounds;
- wherein FAP stands for an anion of the following formula (I),
- [P(CnF2n+1)yF6−y]− (I),
- where
- n stands on each occurence, independently, for 1, 2, 3, 4, 5, 6, 7 or 8, and
- y stands for 1, 2, 3 or 4.
2 more elements
Dependencies are inferred from the claim text.