Autophagy inhibitors

A compound of formula III

• or a pharmaceutically acceptable salt thereof, wherein:
• Q is —CH;
• RN is —H;
• R1 is —H, —F, —Cl, —Br, or —CF3;
• R2 is —CH(R2-1)-(CH2)n2—X;
• R2-1 is —H, or —C3 cycloalkyl;
• n2 is 3;
• X is —NX1-2X1-3, wherein
• X1-2 is —H, linear or branched —C1-C4 alkyl, -cyclopropyl, -cyclobutyl, or —SO2—X1-4, wherein X1-4 is selected from the group consisting of:
• —H, —C1-C3 alkyl, and —CO—X1-4, wherein X1-4 is as defined above;
• X1-3 is linear or branched —C1-C4 alkyl substituted with one cyclopropyl;
• R3 is —H, —CF3, —OR3-1, wherein R3-1 is —H, —C1-C6 alkyl, —CO—R3-2, wherein R3-2 is —C1-C3 alkyl or -phenyl, —N(R3-1)2, wherein the R3-1 are the same or different and are as defined above, —SR3-1, wherein R3-1 is as defined above, —S(O)—R3-1 wherein R3-1 is as defined above, or —SO2—R3-1, wherein R3-1 is as defined above;
• R4 is —H, —F, —Cl, —Br, —CF3, —OR4-1, wherein R4-1 is —H, C1-C6 alkyl or —CO—R4-2, wherein R4-2 is C1-C3 alkyl or phenyl, —N(R4-1)2, wherein the R4-1 are the same or different and are as defined above, —SR4-1, wherein R4-1 is as defined above, —S(O)—R4-1, wherein R4-1 is as defined above, or —SO2—R4-1, wherein R4-1 is as defined above;
• and
• R5 is —H, —F, —Cl, —Br, —CF3, —OR5-1, wherein R5-1 is —H, —C1-C6 alkyl or —CO—R5-2 wherein R5-2 is —C1-C3 alkyl or -phenyl, —N(R5-1)2, wherein the R5-1 are the same or different and are as defined above, —SR5-1, wherein R5-1 is as defined above, —S(O)—R5-1, wherein R5-1 is as defined above, or —SO2—R5-1, wherein R5-1 is as defined above;
• with the proviso that one of R1, R3, R4 and R5 must be other than —H.