Anthraquinone analogs and methods of making and using thereof

A method of treating leukemia comprising administering to a patient in need thereof a pharmaceutical composition comprising an effective amount of one or more compounds having formula:

• wherein
• X, Y, W, and Z are independently O;
• R1 and R8 are independently substituted or unsubstituted C1-C30 alkyl, or substituted or unsubstituted arylalkyl;
• R3 is NR9—CO—(CH2)nR10, wherein n is independently an integer from 0-10 and each occurrence of R9 is independently hydrogen, C1-C30 alkyl, or C5-C7 aryl, and R10 is halogen, azide, cyano, C1-C30 alkoxy, aroxy, benzyloxy, trifluoromethyl, vinyl group, hydroxy, amino, primary amine, or secondary amine;
• R2 and R4-R7 are independently hydrogen, —OH, —SH, ether, thioether, primary amine, secondary amine, tertiary amine, ester, carboxylic acid, primary amide, secondary amide, tertiary amide, sulfonyl group, phosphate, nitro, halogen, nitrile, trifluoromethyl, or substituted or unsubstituted C1-C30 alkyl, C1-C30 heteroalkyl, C2-C30 alkenyl, or C2-C30 alkynyl;
• and
• wherein substituents for the substituted groups are independently halogen, hydroxyl, C1-C30 alkyl, C2-C30 alkenyl, C2-C30 alkynyl, phenyl, C5-C7 aryl, C5-C7 heteroaryl, C3-C10 cycloalkyl, C3-C10 heterocycloalkyl, alkoxy, phenoxy, aroxy, alkylthio, phenylthio, cyano, isocyano, carbonyl, carboxyl, amino, amido, sulfonyl, sulfonic acid, phosphoryl, or phosphonyl.