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US 10,544,075 B2Granted
Derivatives of sobetirome
AssigneeOregon Health & Science University
InventorsThomas Scanlan, Jordan Devereaux, Andrew Placzek, Tapasree Banerji, Skylar Ferrara, James Matthew Meinig, Tania Banerji
Life of this patent
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Abstract
Disclosed are halo substituted derivative compounds of sobetirome with improved pharmacological characteristics relative to sobetirome, pharmaceutical compositions that include those compounds and methods of treating diseases such as neurodegenerative disorders using those pharmaceutical compositions.
Claims22
A compound according to Formula I
- or any pharmaceutically acceptable salt thereof, wherein:
- R1 and R2 are independently selected from the group consisting of fluoro, chloro, bromo, and iodo, and
- R3 is independently selected from the group consisting of —OH and —NR3aR3b,
- R3a is independently selected from hydrogen and C1-6 alkyl, and
- R3b is C1-6 alkyl.
2 more elements
Dependencies are inferred from the claim text.