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US 10,543,286 B2Granted
Methods for increasing platelet count by inhibiting biliverdin IXβ reductase
AssigneeThe Research Foundation for The State University of New York
InventorsWadie F. Bahou, Song Wu
Life of this patent
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Abstract
The present disclosure provides methods of treating a human having a disease or disorder that would benefit from increasing platelet counts. The method involves inhibiting the enzyme activity of biliverdin IXβ reductase (BLVRB) activity or inhibiting the expression of BLVRB gene.
Claims13
A method of increasing platelet counts of a subject, the method comprising:
- administering to the subject therapeutically effective amount of an agent that inhibits biliverdin IXβ reductase (BLVRB) enzymatic activity, wherein the agent is 4-((6-Chloro-2-methoxyacridin-9-yl)amino)-2-((4-methylpiperazin-1-yl)methyl)phenol and wherein the agent increases the platelet count of the subject.
A method of increasing platelet counts of a subject, the method comprising:
- administering to the subject therapeutically effective amount of an agent that inhibits biliverdin IXβ reductase (BLVRB) enzymatic activity and increases the platelet count of the subject.
Dependencies are inferred from the claim text.