US 10,540,536 B2 · System for interpretation of image patterns in terms of anatomical or curated patterns

Abstract

Imaging mass spectrometry (IMS) has become a prime tool for studying the distribution of biomolecules in tissue. Although IMS data sets can become very large, computational methods have made it practically feasible to search these experiments for relevant findings. However, these methods lack access to an important source of information that many human interpretations rely upon: anatomical insight. In this work, this need is addressed by (1) integrating a curated anatomical data source with an empirically acquired IMS data source, establishing an algorithm-accessible link between them; and (2) demonstrating the potential of such an IMS-anatomical atlas link by applying it toward automated anatomical interpretation of ion distributions in tissue.

Claims20

Dependent claims

A method for facilitating interpretation of image patterns indicative of spatial distribution of a property using curated image patterns, the method comprising:

receiving an image pattern to interpret (IPTI) and a set of curated image patterns, wherein the IPTI and at least one curated image pattern of the set of curated image patterns have been spatially registered to a common set of spatial locations;
defining a model structure of a relationship between the IPTI and at least one curated image pattern using the common set of spatial locations, wherein one or more models that correspond to the model structure comprise coefficients and parameters and each set of different model coefficients and parameters represents a different interpretation of the IPTI;
and
selecting a model of the one or more models that optimizes an objective function.

1 more element

A device for facilitating interpretation of image patterns related to a property of interest using curated image patterns, the device comprising:

a non-transitory storage medium having software instructions stored thereon;
and
a processor configured to receive an image pattern to interpret (IPTI) from an imaging device and to receive a set of curated image patterns that are spatially registered to a common set of spatial locations, wherein the processor is further configured to execute the software instructions to perform the steps of:
defining a model structure of a relationship between the IPTI and the at least one curated image pattern using the common set of spatial locations, wherein one or more models that correspond to the model structure comprise coefficients and parameters and each set of different model coefficients and parameters represents a different interpretation of the IPTI;
and
selecting a model of the one or more models that optimizes an objective function.

3 more elements

Dependencies are inferred from the claim text.

System for interpretation of image patterns in terms of anatomical or curated patterns

Life of this patent

System for interpretation of image patterns in terms of anatomical or curated patterns

Life of this patent

Abstract

Claims20