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US 10,539,577 B2Granted
Fibroblast growth factor receptors as diagnostic markers of acquired sensory neuronopathies
AssigneesInstitut National De La Sante Et De La Recherche Medicale (Inserm), Centre National De La Recherche Scientifique, Universite Jean Monnet Saint Etienne, Universite Claude Bernard Lyon 1, Hospices Civils De Lyon, Centre Hospitalier Universitaire de Saint Etienne
InventorsJerome Marc Claude Honnorat, Jean-Christophe Antoine, Jean-Philippe Camdessanche, Nadia Boutahar, Veronique Annie Rogemond
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Abstract
The present invention relates to the diagnosis of acquired sensory neuronopathies (SNN), and to the treatment of these disorders.
Claims2
An analytical method comprising
- a) obtaining a biological sample from a patient having or suspected of having an acquired sensory neuronopathy, and
- b) detecting, in the biological sample, antibodies toward a fibroblast growth factor receptor (FGFR) family protein by contacting the sample with
- i) a protein which comprises a TRK 1 subunit of the intracellular kinase domain of FGFR3 of NCBI accession number NP_000133 (i.e. fragment 403-660 of FGFR3 of NCBI accession number NP_000133;
- SEQ ID NO:
- 12);
- or
- ii) a protein which comprises a TRK2 subunit of the intracellular kinase domain of FGFR3 of NCBI accession number NP_000133 (i.e. fragment 661-792 of FGFR3 of NCBI accession number NP_000133;
- SEQ ID NO:
- 13), and
- detecting binding between the antibodies toward the FGFR family protein and i) the protein which comprises a TRK 1 subunit of the intracellular kinase domain of FGFR3 of NCBI accession number NP_000133 (i.e. fragment 403-660 of FGFR3 of NCBI accession number NP_000133;
- SEQ ID NO:
- 12);
- or ii) the protein which comprises a TRK2 subunit of the intracellular kinase domain of FGFR3 of NCBI accession number NP_000133 (i.e. fragment 661-792 of FGFR3 of NCBI accession number NP_000133;
- SEQ ID NO:
- 13).
12 more elements
An analytical method comprising
- a) obtaining a biological sample from a patient having or suspected of having an acquired sensory neuronopathy and
- b) detecting, in the biological sample, antibodies toward a fibroblast growth factor receptor (FGFR) family protein by contacting the sample with
- i) a protein which consists of a TRK 1 subunit of the intracellular kinase domain of FGFR3 of NCBI accession number NP_000133 (i.e. fragment 403-660 of FGFR3 of NCBI accession number NP_000133;
- SEQ ID NO:
- 12);
- or
- ii) a protein which consists of a TRK2 subunit of the intracellular kinase domain of FGFR3 of NCBI accession number NP_000133 (i.e. fragment 661-792 of FGFR3 of NCBI accession number NP_000133;
- SEQ ID NO:
- 13), and detecting binding between the antibodies toward the FGFR family protein and i) the protein which consists of a TRK 1 subunit of the intracellular kinase domain of FGFR3 of NCBI accession number NP_000133 (i.e. fragment 403-660 of FGFR3 of NCBI accession number NP_000133;
- SEQ ID NO:
- 12);
- or ii) the protein which consists of a TRK2 subunit of the intracellular kinase domain of FGFR3 of NCBI accession number NP_000133 (i.e. fragment 661-792 of FGFR3 of NCBI accession number NP_000133;
- SEQ ID NO:
- 13).
11 more elements
Dependencies are inferred from the claim text.