Lung cancer differential marker

A method for determining whether a test subject afflicted with lung cancer is afflicted with adenocarcinoma comprising:

• (i) detecting a lung cancer differential marker glycoprotein glycosylated with a glycan at an asparagine residue or at least one fragment thereof in a sample obtained from the test subject, and
• (ii) determining whether the test subject is afflicted with adenocarcinoma by determining whether the glycoprotein or the fragment thereof is present in the sample;
• wherein the presence of the glycoprotein or fragment in the sample indicates that the test subject is afflicted with adenocarcinoma, and the absence of the glycoprotein or fragment in the sample indicates that the test subject is not afflicted with adenocarcinoma, and wherein:
• (a) the lung cancer differential marker glycoprotein is fibronectin 1, and the glycoprotein and the fragment thereof comprise the amino acid sequence;
• (b) the lung cancer differential marker glycoprotein or the fragment thereof is detected using at least one glycan probe that binds to a fucosylated glycan or β1,3-galactose wherein the glycan probe is PNA lectin;
• and
• (c) the sample is a body fluid, lung cancer tissue or a lung lavage.