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US 10,539,557 B2Granted
AH-7921 Detection
AssigneeRandox Laboratories Limited
InventorsElouard Benchikh, Ivan McConnell, Peter FitzGerald, Philip Lowry
Life of this patent
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Abstract
Antibodies, immunoassay methods and kits for the detection and determination of 3,4-dichloro-N-[(1-(dimethylamino)cyclohexyl)methyl]benzamide and 3,4-dichloro-N-[(1-(methylamino)cyclohexyl)methyl]benzamide, as well as the precursory immunogens, are described.
Claims11
A polyclonal antibody raised against an immunogen of the structure:
- wherein the antibody binds to (i) 3,4-dichloro-N-[(1-(dimethylamino)cyclohexyl)methyl]benzamide and (ii) 3,4-dichloro-N-[(1-(methylamino)cyclohexyl)methyl]benzamide, and
- wherein the antibody has a relative cross-reactivity of 100% to 3,4-dichloro-N-[(1-(dimethylamino)cyclohexyl)methyl]benzamide and 94.186% to 3,4-dichloro-N-[(1-(methylamino)cyclohexyl)methyl]benzamide, wherein the cross-reactivity is measured in the presence of a detecting agent comprising N-(carboxypropyl)-3,4-dichloro-N-[1-(methylamino)cyclohexyl)methyl]benzamide conjugated to horseradish peroxidase.
Dependencies are inferred from the claim text.