Thin film bulk acoustic resonator with signal enhancement

A system for detecting an analyte in a sample, comprising:

• a thin film bulk acoustic resonator (TFBAR) comprising a surface to which a first recognition component is immobilized,
• the first recognition component being configured to selectively bind the analyte, an analyte molecule to which a tag is linked, or a tag, or any one of these molecules to which an amplification element-linked second recognition component is bound,
• the TFBAR having a resonance band of about 2 GHz to about 10 GHz;
• one or more containers housing an amplification molecule, the amplification element-linked second recognition component, and optionally one or both of the tag and the analyte molecule;
• a fluid path from the one or more containers to the surface of the TFBAR to which the first recognition component is bound;
• actuation circuitry configured to drive the TFBAR in an oscillating motion;
• measurement circuitry arranged to be coupled to the TFBAR and configured to measure one or more resonator output signals representing resonance characteristics of the oscillating motion of the sensing resonator;
• and
• a controller operatively coupled with the actuation and measurement circuitry.