Apparatus and method for measuring erythrocyte sedimentation rate
AssigneeGwangju Institute of Science and Technology
InventorsSung Yang, Alexander Zhbanov
Life of this patent
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Abstract
An apparatus and method for measuring an erythrocyte sedimentation rate based on a change in conductivity of blood over time. The apparatus for measuring an erythrocyte sedimentation rate may include: a chamber for holding blood; a pair of electrodes being partially or completely brought into contact with the blood; and a conductivity meter measuring the conductivity through the pair of electrodes. The apparatus and method according to the present invention are less time-consuming than the Westergren method and can acquire a variety of information (for example, hematocrit, dynamics of the sedimentation rate and aggregation of erythrocytes, a relationship between the sedimentation rate and aggregation of erythrocytes, and the like).
Claims8
A method for measuring an erythrocyte sedimentation rate based on a change in conductivity of blood over time, comprising:
- introducing blood into a chamber;
- and
- measuring conductivity of the blood using a pair of electrodes,
- wherein the change in conductivity is found based on a difference between conductivities measured at two points of time,
- wherein the two points of time are selected from a time section after the conductivity starts to decrease,
- wherein the erythrocyte sedimentation rate is measured through comparison of the change in conductivity with an erythrocyte sedimentation rate measured by the Westergren method, and
- wherein a relationship between the change in conductivity and the erythrocyte sedimentation rate measured by the Westergren method is represented by the following equation:
- Δσ=λWγ
- where Δσ denotes a difference (unit:
- S/m) between conductivities of the blood measured at predetermined points of time, denotes an erythrocyte sedimentation rate (unit:
- mm/h) measured by the Westergren method, and λ and γ denote fitting parameters, wherein the fitting parameters are calculated by regression analysis.
A method for measuring an erythrocyte sedimentation rate based on a change in conductivity of blood over time, comprising:
- introducing blood into a chamber;
- and
- measuring conductivity of the blood using a pair of electrodes,
- wherein the change in conductivity is found based on a difference between conductivities measured at two points of time,
- wherein the two points of time are selected from a time section after the conductivity starts to decrease,
- wherein the erythrocyte sedimentation rate is measured through comparison of the change in conductivity with an erythrocyte sedimentation rate measured by the Westergren method, and
- wherein a relationship between the change in conductivity and the erythrocyte sedimentation rate measured by the Westergren method is represented by the following equation:
- Δσ=λ log(1+W)
- where Δσ denotes a difference (unit:
- S/m) between conductivities of the blood measured at predetermined points of time, and λ denotes an erythrocyte sedimentation rate (unit:
- mm/h) measured by the Westergren method, and denotes fitting parameters, wherein the fitting parameters are calculated by regression analysis.
A method for measuring an erythrocyte sedimentation rate based on a change in conductivity of blood over time, comprising:
- introducing blood into a chamber;
- and
- measuring conductivity of the blood using a pair of electrodes,
- wherein the change in conductivity is found based on a difference between conductivities measured at two points of time,
- wherein the two points of time are selected from a time section after the conductivity starts to decrease,
- wherein the erythrocyte sedimentation rate is measured through comparison of the change in conductivity with an erythrocyte sedimentation rate measured by the Westergren method, and
- wherein a relationship between the change in conductivity and the erythrocyte sedimentation rate measured by the Westergren method is represented by the following equation:
- Δ
-
-
- σ
- =
- λ
-
- W
- W
- +
- γ
- where Δσ denotes a difference (unit:
- S/m) between conductivities of the blood measured at predetermined points of time, denotes an erythrocyte sedimentation rate (unit:
- mm/h) measured by the Westergren method, and λ and γ denote fitting parameters, wherein the fitting parameters are calculated by regression analysis.
A method for measuring an erythrocyte sedimentation rate based on a change in conductivity of blood over time, comprising:
- introducing blood into a chamber;
- and
- measuring conductivity of the blood using a pair of electrodes,
- wherein the change in conductivity is found based on a difference between conductivities measured at two points of time,
- wherein the two points of time are selected from a time section after the conductivity starts to decrease,
- wherein the erythrocyte sedimentation rate is measured through comparison of the change in conductivity with an erythrocyte sedimentation rate measured by the Westergren method, and
- wherein a relationship between the change in conductivity and the erythrocyte sedimentation rate measured by the Westergren method is represented by the following equation:
- Δ
-
-
- σ
- =
- λ
-
- [
- (
- 1
- γ
- )
- 2
- -
- (
- 1
- W
- +
- γ
- )
- 2
- ]
- where Δσ denotes a difference (unit:
- S/m) between conductivities of the blood measured at predetermined points of time, W denotes an erythrocyte sedimentation rate (unit:
- mm/h) measured by the Westergren method, and λ and γ denote fitting parameters, wherein the fitting parameters are calculated by regression analysis.
Dependencies are inferred from the claim text.