Biomarker panel for diagnosis and prediction of graft rejection
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorMinnie M. Sarwal
Life of this patent
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Abstract
Methods are provided for monitoring a subject having a graft for an acute rejection (AR) response, e.g., to predict, to diagnose, and/or to characterize an AR response. In practicing the subject methods, the expression level of at least one gene in a sample from the subject, e.g., a blood or biopsy sample, is evaluated, e.g., at the nucleic acid and/or protein level, to monitor the subject. Also provided are compositions, systems, kits and computer program products that find use in practicing the subject methods.
Claims10
A method of treating a subject who has received an allograft and who is being treated with an immunosuppressive regimen, said method comprising:
- (a) measuring or having measured, in a sample from said subject, the expression level of at least NKTR, MAPK9, DUSP1, PBEF1 and PSEN1 to obtain a gene expression result;
- and
- (b) increasing the immunosuppressive regimen when the gene expression result predicts the onset of an acute rejection (AR) response, is diagnostic of an AR response, and/or characterizes an AR response in said subject;
- or
- reducing the immunosuppressive regimen when the gene expression result predicts that the subject is free of a current and near-term AR response.
Dependencies are inferred from the claim text.