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US 10,538,799 B2Granted
Methods and compositions for expression of polypeptides in a cell
AssigneeCelltheon Corporation
InventorAmita Goel
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Abstract
Disclosed herein are vector systems for expression of polypeptides in eukaryotic cells; and methods of obtaining high-level expression of polypeptides in a eukaryotic cell. Methods and compositions for obtaining stable, long-term expression of recombinant polypeptides are also provided.
Claims6
A polynucleotide comprising a cytomegalovirus (CMV) major immediate early (MIE) promoter consisting of the nucleotide sequence of SEQ ID NO:3, a transgene, a polyadenylation signal, and a woodchuck hepatitis virus post transcriptional regulatory element (WPRE) consisting of the nucleotide sequence of SEQ ID NO:7.
Dependencies are inferred from the claim text.