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US 10,538,790 B2Granted
Bioenzymatic synthesis of THC-v, CBV and CBN and their use as therapeutic agents
AssigneeTeewinot Technologies Limited
InventorsMalcolm J. Kavarana, Richard C. Peet
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Abstract
The present invention provides methods for producing cannabinoids. More specifically, the invention is directed to the bio-enzymatic synthesis of THC-v, CBV and CBN by contacting a compound according to Formula I with a cannabinoid synthase enzyme. Also described is a system for producing these pharmaceutically important cannabinoids and the use of such cannabinoids as therapeutic agents.
Claims16
A method for producing a compound of Formula III:
- wherein R1 is n-propyl or n-pentyl,
- comprising the steps of contacting a compound of Formula I
- in a mixture comprising an aqueous buffer and at least one organic solvent selected from the group consisting of methanol, ethanol, propanol, isopropanol, acetone, dimethylsulfoxide, hexane, and ethylacetate
- with a cannabinoid synthase to produce a compound of Formula II:
- and either
- (A1) oxidizing the compound of Formula II to produce a compound of Formula A:
- and
- (A2) de-carboxylating the compound and of Formula A to produce the compound of Formula III;
- OR
- (B1) de-carboxylating the compound of Formula II to produce a compound of Formula B:
- and
- (B2) oxidizing the compound of Formula B to produce the compound of Formula III.
9 more elements
The method of 1, wherein the compound of Formula II is subjected to steps (A1) and (A2).
Dependencies are inferred from the claim text.