Preventing tumor development and metastasis
AssigneeThe Administrators of the Tulane Educational Fund
InventorsEckhard Alt, Reza Izadpanah
Life of this patent
Estimating the term…
Abstract
Treatment of tumors, especially breast cancer or glioblastoma tumors, by silencing RAB27A and/or TRAF3IP2, compositions and methods for same.
Claims21
A pharmaceutical composition for the treatment of a tumor having increased expression of TRAF3IP2, wherein said composition comprises at least one silencing sequence for TRAF3IP2 in a pharmaceutically acceptable carrier in an amount effective for the therapeutic treatment of a tumor, wherein said silencing sequence reduces the expression of the TRAF3IP2 gene by at least two-fold as comparing to without the silencing sequence for TRAF3IP2, and wherein said silencing sequence is a modified portion of sense strand of NM_001164281.2 (SEQ ID NO. 7), NM_147200.2 (SEQ ID NO. 8), XM_011535386.2 (SEQ ID NO. 9), NM_147686.3 (SEQ ID NO. 10), XM006715319.4 (SEQ ID NO. 11), and NM_001164283.2. (SEQ ID NO. 12) corresponding to exon 9 and/or exon 10 of TRAF3IP2.
A silencing sequence of TRAF3IP2 for use as a medicament or for use in treating a tumor, or solid tumor, or for use in treating glioblastoma or breast cancer, or for use in treating any cancer with at least 2-fold increased TRAF3IP2 expression, wherein said silencing sequence is a modified portion of sense strand of NM_001164281.2 (SEQ ID NO. 7), NM_147200.2 (SEQ ID NO. 8), XM_011535386.2 (SEQ ID NO. 9), NM_147686.3 (SEQ ID NO. 10), XM006715319.4 (SEQ ID NO. 11), and NM_001164283.2. (SEQ ID NO. 12).
Dependencies are inferred from the claim text.