Long-acting coagulation factors and methods of producing same
AssigneeOPKO Biologics Ltd.
InventorsUdi Eyal Fima, Gili Hart
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Abstract
Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotropin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.
Claims26
A CTP-modified polypeptide consisting of a Factor IX coagulation factor and three chorionic gonadotropin carboxy terminal peptides (CTPs) attached to the carboxy terminus of said coagulation factor, wherein said polypeptide does not include an N-terminal propeptide.
A method of extending the biological half-life of a Factor IX (FIX) coagulation factor, comprising the step of attaching three chorionic gonadotropin carboxy terminal peptides (CTP) to the carboxy terminus of said FIX coagulation factor, thereby extending the biological half-life of said coagulation factor, wherein said coagulation factor does not include an N-terminal propeptide.
A method of improving the area under the curve (AUC) of a Factor IX (FIX) coagulation factor, comprising the step of attaching three chorionic gonadotropin carboxy terminal peptides (CTP) to the carboxy terminus of said FIX coagulation factor, thereby improving the AUC of said coagulation factor, wherein said coagulation factor does not include an N-terminal propeptide.
A method of reducing the dosing frequency of a Factor IX (FIX) coagulation factor, comprising the step of attaching three chorionic gonadotropin carboxy terminal peptides (CTP) to the carboxy terminus of said FIX coagulation factor, thereby reducing the dosing frequency of said coagulation factor, wherein said coagulation factor does not include an N-terminal propeptide.
Dependencies are inferred from the claim text.