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US 10,538,746 B2Granted
Polypeptides and variants having improved activity, materials and processes relating thereto
AssigneeInvista North America S.A R.L.
InventorsAlexander Brett Foster, Adriana Leonora Botes
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Abstract
The disclosure relates to polypeptides having carboxylic acid reductase (CAR) activity, including enzymes that catalyse the irreversible reduction of carboxylic acids, such as pimelic acid and adipic acid, to their respective semialdehydes. The enzymes have been engineered to have higher activity over a corresponding wild type enzyme. Provided herein are novel polypeptides and uses thereof related to the same.
Claims4
A polypeptide having at least 95% sequence identity to the amino acid sequence of SEQ ID NO:
- 1, wherein the polypeptide comprises at least one mutation selected from the group consisting of:
- P369S/G/V, S284A/G/T, G380D/E, G619Y/F/L, K692R, A894G/V, A892V/S, P849 G, A880V and C781V/A/S and wherein the polypeptide has carboxylic acid reductase activity.
Dependencies are inferred from the claim text.