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US 10,538,744 B2Granted
Use of adenovirus and nucleic acids coding therefor
OwnerPer Sonne Holminventor
Life of this patent
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Abstract
This invention relates to the use of an adenovirus to treat cancer, for example. The adenovirus may be replication deficient in cells that lack Y box binding protein. The adenovirus may encode an oncogene or an oncogene product, which may transactivate at least one viral gene.
Claims7
A method for the treatment of a subject identified to have a cancerous tumor that expresses Y box binding protein 1 (YB-1), the method comprising:
- administering to the subject in need thereof an AdΔ24 adenovirus that is replication deficient in cells that lack YB-1 in the nucleus, wherein the adenovirus comprises an E1A protein lacking a functional CR2 domain;
- and
- wherein the cancerous tumor, or a portion thereof, is resistant to at least one pharmacological agent.
Dependencies are inferred from the claim text.